NWO Take-Off Grant for organ-on-a-chip development

PhD candidates Cinzia Silvestri, William Quiros Solano and Nikolas Gaio (start-up Biond ) and Ronald Dekker have successfully applied for a NWO Take-Off Grant (Phase 1) for organ-on-a-chip development.

"In vitro screening is a fundamental step during drug development. A crucial need of pharmaceutical companies is to assess drug safety at the early stage of the pipeline to identify and eliminate compounds that exhibit a potential for adverse drug reactions. However, at least 462 medicinal products were withdrawn from the market between 1953 and 2014, with consequences for patients, regulatory systems and pharma companies. Therefore, the traditional screening approach, based on in vitro static cell culture assays, is considered not predictive enough. This limitation has increased the interest in more realistic models: Organs-on-chips (OOCs). Organ-on-Chips are micro-fluidics devices designed to simulate in vivo human physiology by promoting cell and tissue growth in vitro.

BIOND developed an innovative microfluidic system for OOCs that provides a dynamic micro-environment suited to highly predictive cell culture models, that allows real-time recording of a comprehensive set of data of the cell culture with a user-friendly interface. In particular, this project will aim at improving the user interface focusing on three main aspects: Usability, Functionality and Versatility"

PhD thesis Carbon nanotube based solutions for on-chip thermal management

Congratulations to Cinzia Silvestri for her PhD thesis defence on the 7th of July 2017

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Major grant for 'Organ-on-a-chip' research

Photographer: Melvin Tas

The research project NOCI (Netherlands Organ-on-Chip Initiative) has been awarded a prestigious NWO Gravitation subsidy (Zwaartekracht premie) of 18.8 million euros. The program is led by Christine Mummery, Professor of Developmental Biology at the LUMC and UT, and involves five other renowned scientists: Michel Ferrari (neurologist, LUMC), Albert van den Berg (nanotechnologist, UT), Hans Clevers (cell biologist, Hubrecht Institute), Cisca Wijmenga (human geneticist, UMCG) and Lina Sarro (nanotechnologist, TU Delft), all linked to the organ-on-chip consortium Human Organ and Disease Model Technologies (hDMT). NOCI aims at creating a new platform, based on a combination of human stem cells and microchips, to learn more about the development of diseases and to better predict the effect of medicines, and will be a decisive step towards personalized health care.

Prof Lina Sarro: ‘The three-dimensional micro- and nano-structuring of silicon and polymers developed at TU Delft enables us to replicate organ functions precisely and reproducibly. Electrodes and sensors can be integrated in order to provide electromechanical stimulation and read out of the cells. In addition, the IC (integrated circuit)-compatible microfabrication techniques used allow large-scale production with high reproducibility, which is essential for a wide use and later commercialisation of these devices’.

For more information:
EEMCS website
hDMT website

Photograph by: Melvin Tas

PhD thesis Monolithic 3D Wafer Level Integration: Applied for Smart LED Wafer Level Packaging

Congratulations to Zahra Kolahdouz Esfahani for her PhD thesis defense on 19 January 2017

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Best poster award Sense of Contact

Congratulations to Sten Vollebregt for winning the best poster award at the 18th Sense of Contact conference!

3 papers accepted @ IEEE MEMS 2017

For the second year in a row, ECTM will be present at the IEEE MEMS conference , the flagship conference in this field, with 3 papers! Congratulations to Cinzia, Violeta, Aleksandar and all co-authors!

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Vacancy: Team manager for Electrical Engineering Education (EEE)

The Faculty of EEMCS is creating a special team to fully focus on teaching using our unique and innovative ‘Delft method’. This method integrates practical and theoretical electrical engineering education and trains students to be hands-on, theoretically versed electrical engineers ready for a future career in science or industry.

We are looking for a team manager specialising in Electrical Engineering Education (EEE) who will be both a group leader and a teacher in his/her capacity as the role model of EE Education.

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Best student lecture award Eurosensors

On the closing ceremony of the XXXth Eurosensors Conference, held in Budapest, Hungary from 4 to 7 September, the Best Student Lecture Award was given to: Ronald Stoute et al. Intravascular Ultrasound at the tip of a guidewire: Concept and first assembly steps Congratulations to Ronald and his co-authors!

Thermal characterization of carbon nanotube foam using MEMS microhotplates and thermographic analysis

Thermal material properties play a fundamental role in the thermal management of microelectronic systems. The porous nature of carbon nanotube (CNT) arrays results in a very high surface area to volume ratio, which makes the material attractive for surface driven heat transfer mechanisms. Here, we report on the heat transfer performance of lithographically defined micropins made of carbon nanotube (CNT) nanofoam, directly grown on microhotplates (MHPs). The MHP is used as an in situ characterization platform with controllable hot-spot and integrated temperature sensor. Under natural convection, and equivalent power supplied, we measured a significant reduction in hot-spot temperature when augmenting the MHP surface with CNT micropins. In particular, a strong enhancement of convective and radiative heat transfer towards the surrounding environment is recorded, due to the high aspect ratio and the foam-like morphology of the patterned CNTs. By combining electrical characterizations with high-resolution thermographic microscopy analysis, we quantified the heat losses induced by the integrated CNT nanofoams and we found a unique temperature dependency of the equivalent convective heat transfer coefficient, Hc. The obtained results with the proposed non-destructive characterization method demonstrate that significant improvements can be achieved in microelectronic thermal management and hierarchical structured porous material characterization.

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Prof. Sarro appointed Knight of the Order of the Star of Italy (OSI) by the President of the Italian Republic, Sergio Mattarella

On March 14, the Italian ambassador, Francesco Azzarello, presented the award to Prof. Sarro at the Italian embassy in The Hague, in the presence of the Rector, Prof Karel Luyben, and the Dean of the EEMCS faculty, Prof Rob Fastenau.

the Order of the Italian Star rewards Italian people who distinguish themselves abroad and deepen relations between Italy and other countries. Prof Sarro was elevated in recognition of her academic merits and prestigious achievements

PhD thesis Multi-Scale Material and Technology for Heterogeneous Integration

Congratulations to Rene Poelma for his PhD thesis defense on January 20, 2016

PhD thesis Interface Properties of Grouo-III-Element Deposited-Layers Integrated in High-Sensitivity Si Photodiodes

Congratulations to Lin Qi for his PhD thesis defense on January 18, 2016

Happy 2016!

Here are some pictures of the New Year Reception of the Microelectronics department

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Nikolas Gaio has won Best Student Paper Award

Nikolas Gaio, PhD of the Electronics Components, Technology Materials Group has won the Best Student Paper Award on the IEEE Sensor 2015 Conference in Busan (South Korea)1-4 November 2015

The title of his paper is: Upside-down Carbon Nanotube (CNT) Micro-electrode Array (MEA), other authors are: B. van Meer, C. Silvestri, S. Pakazad, S. Vollebregt, C.L. Mummery, R. Dekker.

PhD thesis Organic Materials Degradation in Solid State Lightning Applications

Congratulations to Maryam Yazdan Mehr for her PhD thesis defense on November 23, 2015

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TU Delft Female Fellowship Tenure Track Openings

Academic openings at all professor levels

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The direct growth of carbon nanotubes as vertical interconnects in 3D integrated circuits

An article of Ryoichi Ishihara and Sten Vollebregt from the ECTM group of the Microelectronics Department has been published in the magazine Carbon on September 30 2015. Ishihara and Vollebregt managed to integrate for the first time carbon nanotubes with transistors. They demonstrated that these processes are compatible with each other.

Project information

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QuTech enters in collaboration with Intel

Intel and QuTech, the quantum institute of TU Delft and TNO, have finalised plans for a ten-year intensive collaboration, along with financial support for QuTech totalling approximately $50 million.

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PhD thesis Silicon Carbide Technologies applied to MEMS Nanoreactors for in-situ Transmission Electron Microscopy

Congratulations to Bruno Morana for his PhD thesis defense on July 17, 2015

ISCAS 2015 Keynote Presentation Ronald Dekker online

Ronald Dekker's Keynote: From Chips for the Living to Living Chips

Micro-fabricated devices are finding their way to the frontend of medical equipment, where they are the interface between body, or in general living tissue, and machine. They enable better and cheaper diagnostic equipment, they add eyes and ears to minimally invasive instruments such as laparoscopic instruments and catheters, they allow for un-obtrusive monitoring of body functions, they add functionality to implants, and they enable the development of better and personalized medicines. Despite their great promise it has been proven difficult to bring these devices out of the laboratory phase into production. One of the reasons is the lack of a suitable fabrication infrastructure. Much more than standard CMOS or MEMS devices, these medical devices rely on the processing of novel materials, especially polymers, in combination with advanced molding, micro-fluidics, and assembly technologies. At the same time these devices have to be fabricated under strict quality control conditions in a certified production environment.

In the recently granted ECSEL project InForMed a supply chain for the pilot fabrication of these medical devices is organized, which brings together key European technology partners in an integrated infrastructure linking research to pilot and high volume production. The pilot line is hosted by Philips Innovation Services, and open to third party users.

Speaker Biography:

Ronald Dekker received his MSc in Electrical Engineering from the Technical University of Eindhoven and his PhD from the Technical University of Delft. He joined Philips Research in 1988 where he worked on the development of RF technologies for mobile communication. Since 2000 his focus shifted to the integration of complex electronic sensor functionality on the tip of the smallest minimal invasive instruments such as catheters and guide-wires. In 2007 he was appointed part time professor at the Technical University of Delft with a focus on Organ-on-Chip devices. He published in leading Journals and conferences and holds in excess of 50 patents.

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PhD thesis Development of Silicon Drift Detectors using Boron layer technology

Congratulations to Negin Golshani for her PhD thesis defense on June 29, 2015

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PhD thesis High Aspect-Ratio MEMS Devices for the next generation of THZ/MHZ Passive Components

Congratulations to Giuseppe Fiorentino for his PhD thesis defense on June 16, 2015

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PhD thesis Stretchable Micro-Electrode Arrays for Electrophysiology

Congratulations to Saeed Khoshfetrat Pakazad for his PhD thesis defense on June 15, 2015

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Printing Silicon on Paper, with Lasers

A recent publication by Ryoichi Ishihara and Miki Trifunovic in Applied Physics Letters has been highlighted by the American Institute of Physics

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Congratulations to Prof. dr. Sarro with her royal honour

Professor Lina Sarro, professor of micro-electronics at the Faculty of Electrical Engineering, Mathematics and Computer Science, has been made a Knight in the Order of the Netherlands Lion, in The Hague.

She received the award because of her original research that resulted in a large scientific body of work and because of her in-depth involvement with her many students. Her pioneering work in the 1980s in the field of infrared sensors led to international acclaim. Since 1987, she has been in charge of research into micro and nanosystems (MEMS and NEMS) at the Else Kooi Lab, which was known previously as the Dimes Institute for Microsystems and Nanoelectronics.

Professor Sarro has published more than 200 articles in scientific journals and has received awards for her work on several occasions. In 2004, she received the Eurosensors Fellow Award, in 2007 the AISEM Career Award, and in 2012 the IEEE Sensors Council Meritorious Award. She is also a member of the Royal Netherlands Academy of Arts and Sciences (KNAW) and a fellow of the Institute of Electrical and Electronics Engineers. She has been praised on account of both her scientific work and her unfailing commitment to providing teaching of a high standard.

To her students, from both inside and outside the Netherlands, she is a figurehead. This applies perhaps in particular to female students and academics. In 2005, Professor Sarro became the first female to join the TU Delft Council of Professors. She is dedicated to emphasising the role of female scientists, in the conviction that it is a waste to use only half of our scientific assets. Her outstanding scientific reputation ensures that her voice is heard in this, and in other issues.

PhD thesis Fast Qualification of Solder Reliability in Solid-state Lightning System

Congratulations to Jing Zhang for his PhD thesis defense on April 24, 2015

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PhD thesis Single-grain Silicon Technology for Large Area X-ray Imaging

Congratulations to Aslıhan Arslan for her PhD thesis defense on April 14, 2015

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Else Kooi Award ceremony at ICT Open

The winner Daniele Raiteri, photo: Thijs ter Hart

The 2015 Else Kooi Award has been granted to Dr Daniele Raiteri for his scientific research on Technology-Aware Circuit Design for Smart Sensors on Plastic Foils. The Else Kooi Award is an annual award for young researchers in the field of applied semiconductor research conducted in the Netherlands. The award comes with a prize of 5,000 euros.

Raiteri has received the award during a special ceremony at the ICT.OPEN symposium on March 25th. The award was presented by the board of the Else Kooi Award foundation professor Nauta, chair of the foundation (TU Twente) and professor Edoardo Charbon. Edoardo Charbon from the microelectronics department of the EEMCS faculty holds the position of secretary of the Else Kooi Award Foundation.

Dr Raiteris research is focused on organic semiconductors. This emerging technology has specific features which severely complicate the design of circuits and systems, such as low transconductance, gain and speed, as well as high component variability. Dr Raiteri has devised several new solutions that have shown to be extremely robust to variability, achieving significantly better gain-bandwidth products in amplifiers and exceptional signal-to-noise ratios in voltage-controlled oscillators.

Photos by: Thijs ter Hart

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PhD thesis Low temperature PureB technology for CMOS compatible photodetectors

Congratulations to Vahid Mohammadi for his PhD thesis defense on March 9, 2015

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PhD thesis Liquid-Si Technology for High-Speed Circuits on Flexible Substrates

Congratulations to Jin Zhang for her PhD thesis defense on January 26, 2015

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Farewell symposium Prof. dr. Kees Beenakker

On the 11th November the 'Prof. Beenakker Symposium' was held to say farewell to Kees Beenakker, which became emeritus. The speakers of the symposium consisted of guests from industry and academia: NWO, Tsinghua University, Philips Lightning, Boschman BV and TU Delft, and was attended by many guests and students.

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QuTech appointed as 'national icon'

The Ministery of Economic Affairs has named 4 innovations as 'national icon'; QuTech is one of them. "National icons are innovations which generate future welfare and help to solve mondial problems." The icons will receive a national support podium, including a minister or secretary of state as ambassador.

In the Department of Microelectronics, prof. Edoardo Charbon and dr. Ryochi Isihara are 2 of the 5 EWI faculty members directly involved in QuTech.

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IEEE Sensors 2014 best paper awards

Congratulations to Cinzia and Ronald for getting the IEEE Sensors best paper awards in topic 1 and 8!

Best poster prize at EEMCS PhD event

Congratulations to Yelena Grachova for winning the best poster prize of the faculty PhD event

Fast and inexpensive roll-to-roll manufacturing of silicon transistors on plastic films

The research of Dr. Ishihara on the low temperature fabrication of flexible electronics on plastics is featured in this quarter's edition of the Delft Outlook.

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PhD thesis A Systematic Approach to Address the Reliability of Solid State Lighting Drivers

Congratulations to Sima Tarashioon for her PhD thesis defense on September 18, 2014

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PhD thesis Thermal Management of Solid State Lighting Module

Congratulations to Huaiyu Ye for his PhD thesis defense on September 10, 2014

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PhD thesis SiGe heterojunction bipolar transistors with Schottky collector contacts

Congratulations to Gianpaolo Lorito for his PhD thesis defense on September 9, 2014

Paper selected for frontispiece of Advanced Functional Materials

Congratulations to Ren Poelma et al. for their paper in Advanced Functional Materials being selected as frontispiece.

Micromachined nanoreactors fabricated in DIMES enable the study of catalyst dynamics under industrial operating conditions

A unique collaboration between microsystems technology specialists of the ETCM group of the Microelectronics Department of TU Delft and catalyst researchers from industry (Haldor Topsoe, Albemarle Corporation) and universities (TU Delft, Leiden) has led to an innovative method to study catalyst dynamics under industrial operating conditions.

The process uses a technique called high-resolution electron microscopy to monitor atomic changes in the catalyst structure during the catalytic process. Unlike conventional electron microscopy, which has considerable pressure and temperature limitations, this new technique allows scientists to view these reactions under real-life (in-situ) conditions.

The key to the success of this new technique is the surface micromachined nanoreactor. This revolutionary device has been designed by members of the ECTM group and fabricated in DIMES. The device is a miniaturize gas reaction chamber consisting of a surface micromachined channel interfaced by gas inlets/outlets. It integrates a microheater to locally provide high temperatures, and electron transparent windows to observe the in-situ reactions between gases and catalyst nanoparticles.

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Nature material publication: Visualization of oscillatory behaviour of ​Pt nanoparticles catalysing ​CO oxidation

Information about the design

ECTM-Dimes excursion to SRON, Castle de Haar and Utrecht

On the 30th of June the annual ECTM-Dimes excursion was held, consisting of a visit to SRON and Castle de Haar and a tour through the canals in Utrecht

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PhD thesis AlN Piezoelectric Films for Sensing and Actuation

Congratulations to Tran Trong An for his PhD thesis defense on April 16, 2014

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PhD thesis Carbon Nanotubes as Vertical Interconnects in 3D Integrated Circuits

Congratulations to Sten Vollebregt for his PhD thesis defense on March 7, 2014

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Best paper award

Congratulations to Sten Vollebregt for his Best Paper Award @ ITC 2014

PhD thesis MIP Plasma Decapsulation of Copper-wired Semiconductor Devices for Failure Analysis

Congratulations to Jiaqi Tang for his PhD thesis defense on Januari 15, 2014

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PhD thesis IC Compatible Wafer Level Fabrication of Silicon Nanowire Field Effect Transistors for Biosensing Applications

Congratulations to Thomas Moh Shan Yau for his PhD thesis defense on December 9, 2013

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IEEE Fellow

Congratulations to Prof. Kouchi Zhang for being an IEEE Fellow

Best Paper Award

Congratulations to Jin Zhang for her Best Paper Award @ “AM-FPD” 2013

Eurosensors 2013 Fellow Award

Congratulations to Fredrik Creemer for his Eurosensors 2013 Fellow Award @Transducers 2013, Barcelona

PhD thesis Flexible Sensors for Minimally Invasive Medical Instruments

Congratulations to Benjamin Mimoun for his PhD thesis defense on April 22, 2013

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PhD thesis Hybrid Wafer-Level Packaging for RF MEMS and Optoelectronic Applications

Congratulations to Jun Tian for his PhD thesis defense on March 7, 2013

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PhD thesis Light management in thin-film silicon solar cells

Congratulations to Olindo Isabella for his PhD thesis defense on January 28, 2013

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